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Despite (n.) Malice; malignity; spite; malicious anger; contemptuous hate.
Despite (n.) An act of malice, hatred, or defiance; contemptuous defiance; a deed of contempt.
Despite (n.) To vex; to annoy; to offend contemptuously.
Despite (prep.) In spite of; against, or in defiance of; notwithstanding; as, despite his prejudices.